نوع المستند : المقالة الأصلية
المؤلفون
1
Nutrition and Food Science Dept., Faculty of Home Economics, Helwan University
2
MSc student, Nutrition and Food Science Dept, Faculty of Home Economics, Helwan University, Egypt
3
Nutrition and Food Science, Nutrition and Food Science Dept., Faculty of Home Economics, Arish University
10.21608/jhe.2025.465758
المستخلص
Centaurea species possess bioactive compounds with liver-protective and antioxidant potential. This study aimed to assess the hepatoprotective potential of Centaurea cineraria and Centaurea cyanus (cornflower), individually and in combination, against paracetamol-induced liver toxicity in rats. It also investigated their chemical composition, phenolic constituents, and the histopathological alterations in hepatic tissues. Forty-eight male albino rats were assigned to eight groups: a negative control, a paracetamol-induced hepatotoxic control, and six treatment groups fed diets containing C. cineraria or C. cyanus at 5% or 10%, either individually or in combined ratios of 2.5%+2.5% and 5%+5%. Biochemical parameters, including liver enzymes (AST, ALT, ALP), renal function markers (urea, creatinine, albumin) and oxidative stress indicators (MDA, CAT, SOD, GSH), were estimated, and histopathological examination of liver tissues was conducted to support the biochemical findings. Paracetamol markedly increased liver enzymes, MDA, urea, creatinine and while decreasing albumin and antioxidant markers (SOD, CAT, GSH). Supplementation with C. cineraria and C. cyanus notably improved the altered biochemical parameters, with the 5%+5% combination showing the strongest hepatoprotective effect by normalizing liver enzymes, lowering MDA, and restoring antioxidant markers (SOD, CAT, GSH) toward control levels. Histological examination supported biochemical results, revealing marked improvement in liver structure and a noticeable reduction in hepatic degeneration, most prominently in the groups receiving the combined supplementation.
Conclusion:
C. cineraria and C. cyanus demonstrated significant hepatoprotective and antioxidant effects against paracetamol-induced liver damage, with enhanced efficacy when used in combination. These findings suggest their potential as natural candidates for developing functional foods or nutraceuticals that support liver health.
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