Effect of Synbiotic (Probiotic Bacteria and Prebiotic Mushroom) on Liver Function and Lipid Profile in CCl₄-Induced Hepatotoxic Rats

A. Arafa, Mohamed; M. Rabeh, Naeem; G. El-Masry, Hany; S. Sadek, Dina

doi:10.21608/jhe.2025.464284

Effect of Synbiotic (Probiotic Bacteria and Prebiotic Mushroom) on Liver Function and Lipid Profile in CCl₄-Induced Hepatotoxic Rats

نوع المستند : المقالة الأصلية

المؤلفون

Nutrition and Food Science Dept., Faculty of Home Economics, Helwan University

10.21608/jhe.2025.464284

المستخلص

The study was conducted to investigate Effect of Synbiotic (Probiotic Bacteria and Prebiotic Mushroom) on Liver Function and Lipid Profile in CCl₄-Induced Hepatotoxic Rats. Thirty-five adult male albino, weighing (150 ± 10 g) were divided into 2 main groups, The first main group (n= 7) rats were fed on basal diet and served as a negative control group . The second main group (n=28) were divided into four subgroups as follows: -The first subgroup: fed on basal diet and served as a positive control group. The second subgroup: fed on basal diet supplemented with 5% dried mushroom. The third subgroup: fed on basal diet supplemented with 1 ml of fermented milk (Rayab). The four subgroups: fed on basal diet supplemented with 5% dried mushroom and was given orally 1 ml of fermented milk (Rayab) twice daily . After 4 weeks of starting the experiment, rats in second group was injected with CCl₄ intraperitoneal at (0.1 ml/100 g b. wt.) twice weekly for two weeks. Results indicated that, Supplementation with edible mushroom (5%), rayeb (1 ml), and the combined treatment of mushroom (5%) + rayeb (1 ml) significantly (P < 0.05) increased the final body weight (FBW), body weight gain (BWG %) and feed efficiency ratio as compared to the positive control .Moreover, supplemented with Supplementation with edible mushroom (5%), rayeb (1 ml), or the combined treatment of mushroom (5%) and rayeb (1 ml) significantly (P < 0.05) reduced the relative organ weights compared to the positive control group. Supplementation with edible mushroom (5%), rayeb (1 ml), or the combined treatment of mushroom (5%) and rayeb (1 ml) significantly decreased (P< 0.05) the mean level of serum liver enzymes and serum lipid profile, compared to the control positive group, while serum HDL-C was significantly increased (P< 0.05).Finally, the present study concluded that edible mushroom and rayeb may be given to patients suffer from liver diseases.

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