Protective Effect of Oat and Corn Brans Supplementation Against Fatty Liver in Male Rats

نوع المستند : المقالة الأصلية

المؤلفون

1 Faculty of Nutrition Science, Helwan university, Cairo, Egypt

2 Nutrition of Food Science Dep, Faculty of Home Economics, Helwan university, Cairo, Helwan, Egypt

المستخلص

This study aimed to evaluate the potential protective effects of oat bran and corn bran supplementation against fatty liver disease in male rats. The experimental design included six groups: a negative control group fed a standard diet, a positive control group fed a high-fat diet, and four treatment groups fed a high-fat diet supplemented with either 2.5% or 5% oat bran, or 2.5% or 5% corn bran. Biochemical analyses and histopathological examinations were conducted to assess liver and kidney function, lipid profile, and oxidative stress markers. The results revealed a significant deterioration in liver and kidney function, lipid metabolism, and antioxidant biomarkers in the high-fat diet group compared to the negative control. However, supplementation with oat and corn brans—particularly at the 5% level—resulted in notable improvements in biochemical parameters. These included enhanced liver and kidney functions, reduced lipid peroxidation, increased antioxidant activity, and attenuation of histopathological changes in liver tissue. Oat bran and corn bran supplementation demonstrated protective effects against fatty liver in male rats, with oat bran showing slightly greater efficacy at higher doses. These findings support the potential use of oat and corn brans as functional dietary components in the prevention and management of fatty liver disease.

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