Attenuative Effects of Avocado (Persea americana Mill) and Kiwi (Actinidia deliciosa) Fruits Juice Against Cadmium Induced Hepatotoxicity in Rats

Hassan Shaykhoun, Nada; Ali Ameen, Ahmed; H. Negm, Shaimaa

doi:10.21608/jhe.2025.460652

Attenuative Effects of Avocado (Persea americana Mill) and Kiwi (Actinidia deliciosa) Fruits Juice Against Cadmium Induced Hepatotoxicity in Rats

نوع المستند : المقالة الأصلية

المؤلفون

¹ Nutrition and Food Science Department, Faculty of Home Economics, Helwan University

² Faculty of Nutrition Science, Helwan University

³ Home Economics Department., Specific Education Faculty, Port Said University, Egypt

10.21608/jhe.2025.460652

المستخلص

This study aimed to investigate the protective effects of avocado and kiwi juices against cadmium-induced hepatotoxicity in male rats. Thirty-five rats were used and divided into two main groups. The first main group (n = 7) was fed on a basal diet and served as negative control. The second main group (n = 28) was fed on a basal diet for six weeks and orally administered Cadmium Chloride CdCl₂ (3 mg/kg b.w.) to induce hepatotoxicity. After induction rats were divided as follow: subgroup 1 served as the control positive group and 2, 3 and 4 treated rat subgroups were received 1 ml/day of 10% avocado; kiwi pulp juice; and mixed juice of avocado and kiwi (1:1), respectively. According to the results, HPLC analysis of avocado and kiwi fruits revealed several main components with strong antioxidant properties. Also, avocado fruits content was the highest in phenolic compounds (259.19 mg/100g GAE); flavonoids (2.98mg/100g CE) followed by kiwi fruits. Kiwi fruit is rich in ascorbic acid (15.50 mg/100g). Furthermore, results revealed that Cd exposure significantly elevated liver and kidney enzymes, disrupted lipid profile, and increased oxidative stress markers. Contrast, treatment with avocado and kiwi juices markedly improved these parameters, they caused a significant improve of body weight and increase liver weight, accompanied by improve in levels of liver functions, kidney function, as well as significant improve in levels of lipid profile. In addition, significantly reduced malondialdehyde, while catalase, superoxide dismutase and glutathione activities were significantly (P≤0.05) increased. These findings suggest that avocado and kiwi juices possess potent antioxidant and hepatoprotective properties and could serve as natural dietary protectants against cadmium toxicity.

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