The Anti-neurological Activity of Pomegranate (Punica granatum L.) (Punica granatum L.) and Annona Muricata Linn Pulp Fruit juice in Aluminum Chloride Induced Rats Model

نوع المستند : المقالة الأصلية

المؤلفون

1 Faculty of Home Economics, Helwan University

2 Faculty of Nutrition Science, Helwan University

10.21608/jhe.2025.459327

المستخلص

Pomegranate (Punica granatum L.) (Punica granatum L.) and Annona Muricata fruit juices are rich in bioactive compounds with potent antioxidant and neuroprotective properties. Therefore, this Study was aimed to investigate the anti-neurological disease activity of Pomegranate (Punica granatum L.) and Annona Muricata fruit pulp juice in an aluminum chloride induced rat model. Fifty adult male rats were randomly divided into five equal groups (n = 10 each). The first group (negative control) was fed on basal diet only. The groups were injected with aluminum chloride through intraperitoneal (i.p.) route at a dose of 4.2 mg/kg body weight for 28 (Alcl₃) to induce neurodegeneration (ND), the second group (positive control) received a basal diet. The groups from (3 to 5) received a basal diet and given orally a Pomegranate (Punica granatum L.) juice (PJ) (Punica granatum), Annona Muricata juice (AMJ) and mixture of PJ and AMJ (1:1 v/v) (1 ml/100 g body weight) daily, respectively for one months. Moreover, neurochemical parameters, including acetylcholine concentration, β-hydroxybutyrate, amyloid beta, and hyperphosphorylated tau protein (p-tau) in serum, showed marked (P<0.05) improvement, suggesting a neuroprotective effect. It was also observed that the mixture group exhibiting the most pronounced effects indicating a relatively stronger capacity to modulate tau hyperphosphorylation and mitigate aluminum-induced neuronal damage. So that, these findings support their potential therapeutic application in the prevention and management of neurodegenerative disorders

الكلمات الرئيسية

ملفات

شارك

إرسال الاستشهاد إلى

الإحصائيات