Therapeutic Potential of Pomegranate and Annona muricata Linn. Fruit Juices in Aluminum Chloride-Induced Neurologic Dysfunction: Focus on Oxidative Stress

M. Ghonim, Nancy; M. Rabeh, Naeem; O. Aborya, Alaa

doi:10.21608/jhe.2025.459326

Therapeutic Potential of Pomegranate and Annona muricata Linn. Fruit Juices in Aluminum Chloride-Induced Neurologic Dysfunction: Focus on Oxidative Stress

نوع المستند : المقالة الأصلية

المؤلفون

¹ Faculty of Home Economics, Helwan University

² Faculty of Nutrition Science, Helwan University

10.21608/jhe.2025.459326

المستخلص

Pomegranate (Punica granatum) and Annona Muricata linn fruit juices are rich in bioactive compounds with potent antioxidant and neuroprotective properties. Therefore, this Study was conducted to investigate the antioxidant activity of pomegranate and Annona Muricata fruit pulp juice on aluminum chloride induced rat neurologic disease model. Fifty adult male rats were randomly divided into five equal groups (n = 10 each). The first group (negative control) was fed on a basal diet. The other groups were injected with aluminum chloride (AlCl₃) to induce oxidative stress (OS), the second group (positive control) received basal diet. The other groups (3 : 5) were fed on a basal diet and given orally pomegranate juice (PJ), Annona Muricata juice (AMJ) and mixture of PJ and AMJ (1:1 v/v) at (1 ml/100 g body weight), respectively. The results demonstrated that administration of PJ and AMJ significantly (P<0.05) improved body weight status as compared to the positive control group. Liver functions and oxidative stress biomarkers including malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPX), and total antioxidant capacity (TAC) were significantly (P<0.05) ameliorated in the treated groups. These findings support the potential therapeutic application of both Pomegranate and Annona Muricata fruit juices through their antioxidant effects.

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