نوع المستند : المقالة الأصلية
المؤلفون
1
Nutrition and Food Science Department, Faculty of Home Economics, Helwan University
2
Faculty of Nutrition Science, Helwan University
3
Home Economics Dept., Specific Education Faculty, Port Said University, Egypt
المستخلص
This study aimed to evaluate the potential effect of loquat (Eriobotrya japonica) on hypercholesterolemic rats. Thirty-five adult male rats (Sprague Dawley strain), weighing about 180±10 g were separated into two groups. The 1st group, rats (n=7), was fed on a basal diet and kept as a negative control group. The 2nd group : (hypercholesterolemic rats), (n=28), fed on a hypercholesterolemic diet (high-fat diet (HCD) group). After induction the rats were divided into four subgroups as follows: Subgroup 1 served as the control positive group and 2, 3 and 4 treated rat subgroups were fed on HCD and a diet supplemented with 2.5%, 5% and 7% of dried loquat fruit, respectively. Results revealed that hypercholesterolemic rats treated with 2.5%, 5% and 7.5% of dried loquat fruit caused a significant improvement in body weight and reduced the weights of the heart, lung, liver, kidney, and spleen ,accompanied by a significant decrease in levels of lipid profile as well as in liver functions (ALT, AST and ALP), kidney function (urea, creatinine and uric acid), while These treatments recorded a significant increase in a high-density lipoprotein-cholesterol (HDL-C). In addition, significantly reduced malondialdehyde (MDA) was significantly reduced, while superoxide dismutase (SOD) activity was significantly (P<0.05) increased. In conclusion, loquat fruits demonstrate substantial health potential, exhibiting antihyperlipidemic, anti-hepatic liver, kidney and anti-oxidative stress properties. It also, offers opportunities for the development of functional foods or dietary supplements with potential health benefits.
الكلمات الرئيسية
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