The Therapeutic Effect of Carrot Seed Extract (Daucus carota L.) on Liver and Kidney Injury Induced by Carbon Tetrachloride in Experimental Rats

نوع المستند : المقالة الأصلية

المؤلفون

1 Nutrition and Food Sciences, Home Economics Dept., Fac. Of Specific Education. Aswan

2 Nutrition and Food Sciences, Home Economics Dept., Fac. Of Specifi Education. Ain-Shams

10.21608/jhe.2025.450943

المستخلص

The present study was carried out to investigate the therapeutic effect of carrot seed extract (Daucus carota L.) on liver and kidney injury induced by CCL4  in experimental rats. Following the adaptation period thirty  (30) normal male albino rats (Sprague-Dawely Strain) weighing  200 ± 10 g were randomly  divided into two main groups. The first group (n=6) was a negative control group fed on weighing  diet. The remaining animals (n = 24 rats) were injected with CCl4 which mixed with paraffin oil (50% v/v 2 ml/ kg bwt.) twice a week for two weeks to induce liver and kidney injury. Then divided into 4 group (n=6). The first served as positive control group and the 3rd to 5th group were received carrot seed extract 50, 100, and 200 mg/Kg, respectively. After six weeks of the experiment liver functions, kidney functions and lipid profile were analyzed. The liver and kidney were examined histologically. The results indicated that groups 3, 4, and 5 had lower liver functions than the positive control group. In comparison to the positive control group, all examined groups had significant improvements in kidney functions, cholesterol, triglycerides, and lipid profiles.. The results of histological investigations, which correlated with the biochemical study, significantly improved with the addition of carrot seed extract. Finally, this study suggests that  carrot seed extract  may be useful for patients who suffer from liver and kidney diseases. 

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