Efficacy of The Aqueous Extracts of Guava and Mango Leaves on Diabetic Rats

S. Mohamed, Eman; S. El-Maraasy, Sonia; S. Ibrahim, Eman; G. El-Masry, Hany

doi:10.21608/jhe.2025.448994

Efficacy of The Aqueous Extracts of Guava and Mango Leaves on Diabetic Rats

نوع المستند : المقالة الأصلية

المؤلفون

¹ Nutrition and Food Science Department, Faculty of Home Economics, Helwan University

² Regional Center for Food and Feed, Agriculture Research Center, Giza, Egypt

10.21608/jhe.2025.448994

المستخلص

Diabetes mellitus is a widespread metabolic disorder affecting populations worldwide. Both guava and mango possess significant nutritional value, and their leaves are known for their medicinal properties. The purpose of this study was to evaluate the hypoglycemic potential of aqueous extracts of Guava and Mango leaves either used separately or in a mixture on streptozotocin -induced diabetic rats, also to assess their effects on several biochemical markers associated with diabetes. Thirty male adult rats were divided into five groups, each with six rats as follows: group 1 normal non diabetic rats (negative control); group 2 diabetic untreated rats (positive control); group 3 diabetic treated with guava leaves aqueous extract GLAE) (500 mg/kg b.wt/day); group 4 :diabetic treated with mango MLAE leaves aqueous extract(500 mg/kg b.wt/day); group 5: diabetic treated with mixture of both extracts (500 mg/kg b.wt GLAE+ MLAE ). After four weeks of extracts administration, blood samples were taken to assess several biochemical markers. The results of the present study demonstrated a significant increase in blood glucose level, accompanied by a significant decrease in serum insulin level in diabetic untreated rats (positive control group) relative to normal rats. Additionally, there was a marked elevation in the serum levels of urea, creatinine, and uric acid, as well as in the activities of the liver enzymes AST, ALT, and ALP, compared to the normal rats. In contrast, the daily oral administration of GLAE and MLAE, either individually or in combination, for four weeks to diabetic rats resulted in significant reduction in blood glucose levels and significant improvement in serum insulin levels. These changes were associated with improvements in kidney and liver function, as evidenced by the significant reduction in urea, creatinine, and uric acid levels, along with a significant decrease in the serum activities of AST, ALT, and ALP. Therefore, usage of Guava and Mango Leaves may help to enhancement the status in diabetes mellitus

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