نوع المستند : المقالة الأصلية
المؤلفون
1
Nutrition and Food Science Department, Faculty of Home Economics, Helwan University
2
Faculty of Nutrition Science, Helwan University
3
Home Economics Dept., Specific Education Faculty, Port Said University, Egypt
10.21608/jhe.2025.447743
المستخلص
This study aimed to evaluate the effect of Green Coffee Bean Extract (GCBE) on memory impairment induced by scopolamine in rats. Forty rats were separated into two groups. 1st group, rats (n=8) was fed on basal diet and kept as negative control group, 2st group: (scopolamine group), rats (n=32), were injected with scopolamine (1 mg/kg dissolved in saline, i.p.) for 20 day to induce memory impairment in rats, After ensure the induction of memory impairment then rats were divided into 4 subgroups as follow: subgroup 1 served as the control positive group and 3 treated rat subgroups were orally given 1ml/day of green coffee bean extract at concentration of (5%, 7.5% and 10%), respectively. The results revealed that scopolamine induced promoted acetyl cholinesterase activity, β-amyloid levels and oxidative stress. On the other hand, GCBE demonstrate a significant reduced Acetylcholine esterase activity, β-amyloid levels and oxidative stress markers (MDA) which, improves memory, and antioxidant enzyme levels (SOD, CAT and GSH) in scopolamine- induced rats. Moreover, GCBE to ameliorate the neurological (norepinephrine, dopamine and serotonin), lipid profile (TC, TG, LDL, HDL and VLDL) and liver (ALT, AST and ALP), kidney function (Urea, Creatinine and Uric Acid) in rats. Accordingly, the present study demonstrates the beneficial effects of green coffee bean extract against scopolamine-induced memory impairment. Conclusion, GCBE might become a promising agent for memory improvement in Alzheimer’s disease and AD-like disorder.
الكلمات الرئيسية
)
مشاهدة على SCiNiTO