Effect of Bitter Melon (Momordica charantia) Juice on Blood Glucose Level and Lipid Profile in Diabetic and Prediabetic Rats

نوع المستند : المقالة الأصلية

المؤلفون

Nutrition and Food Science Department, Faculty of Home Economics, Helwan University

المستخلص

This study aimed to evaluate the effect of bitter melon juice (BMJ) on blood glucose level and lipid profile of diabetic and prediabetic rats. Forty-two rats were separated into three group. 1st group, rats (n=6) was fed on basal diet and kept as negative control group, 2st group: (Diabetic): rats (n=18), were injected with a single dose of subcutaneous injection of alloxan (120 mg/kg) to induce diabetes. After diabetes induction rats were divided as follow: subgroup 1 served as the control positive group and 2 treated rat subgroups were fed on basal diet and orally administrated with 1and 2 ml/day of BMJ, respectively. 3st group: (Prediabetic): rats (n=18), High fat diet (HFD) group as induction of prediabetic rats. After prediabetic induction rats were divided as follow: subgroup 1 served as the control positive group and 2 treated rat subgroups were fed on HFD and orally administrated with 1and2ml/day of BMJ, respectively. Results revealed that diabetic and pre diabetic rats treated with oral administration of 1 and 2 ml/day of BMJ caused a significant decrease in blood glucose, increase of insulin. Furthermore, diabetic and pre diabetic rats treated with oral administration of BMJ had improved of body weight accompanied by a significant decrease in levels of lipid profile as well as in  liver functions (ALT, AST and ALP), kidney function (Urea, Creatinine and Uric Acid), while were recorded a significant increase in a high-density lipoprotein-cholesterol (HDL-C). In addition, significantly reduced Malondialdehyde (MDA) while GPX were significantly (P<0.05) increased. Conclusion, bitter melon juice could introduce a potential natural therapy against diabetic and prediabetic. 

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