Hepatoprotective effect of Basil Leaves (Ocimum basilicum L.) on CCl4 induced liver toxicity in rats

نوع المستند : المقالة الأصلية

المؤلفون

1 Nutrition and Food Sciences Dept., Faculty of Home Economics-Helwan University- Egypt

2 Nutrition Science Faculty – Helwan University – Egypt

المستخلص

The present study was designed to investigate the hepatoprotective and antioxidant effects of Basil Leaves (BL) on carbon tetrachloride (CCl4) induced rats’ hepatotoxicity. Animals were (28) albino rats divided into 4 groups. Group 1 was used as a control and received basal diet daily for the period. Group 2 (CCl4 group) rats injected with CCl4: corn oil (1:1) 1 ml/kg, s. c. on 15th day, 18th and 21st day. Group 3(BL protected group) rats feed diet supplemented with (1% (BL) /21days) then injected with CCl4 dose as group 2. Group 4 (BL protected group) rats administered BL (2% BL/ 21 days) then injected with CCl4: as group 2. Biological evaluation parameters were determined (IBW, FBW, FER, BWG%) for rats. Blood samples were separated into serum for liver functions determination (ALT, AST and ALP) and sample for antioxidant parameters determination (MDA and GPx), and lipid profile (TC, TG, HDL-c, LDL-c and VLDL-c). The increase in IBW, FBW, BWG% and FER were significantly ameliorated by the administration of Basil leaves treatments, compared to hepatotoxicity rats. The results revealed that in CCl4 group, there were significant increases in ALT, AST, ALP, TC, TG, LDL-c, VLDL-c and MDA, while the parameters HDL-c and GPx showed significant decreases. Meanwhile, the administration of BL resulted in a significant decrease in all elevated parameters mentioned and an increase in HDL-c and GPx. Therefore, it could be concluded that BL had hepatoprotective and antioxidant role.

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