The present study was designed to investigate the antioxidant and hepatoprotective effects of Senna leaves on carbon tetrachloride (CCl4) induced rats hepatotoxicity. A total of 28 adult male Sprague Dawley albino rats (150 ± 10 g) were obtained from the Experimental Animals Farm, Helwan, Egypt. The first group (n=7) served as the negative control and received a standard basal diet. The second group (n=21) was intraperitoneally injected with carbon tetrachloride (CCl₄) at a dose of 1 mL/kg (1:1 in corn oil) for 3 consecutive days to induce hepatotoxicity. Hepatotoxic rats were then subdivided into three groups (n=7 each): a positive control group fed the basal diet only, and two treatment groups receiving the basal diet supplemented with either 1% or 2% of senna leaves. Biological evaluation parameters were determined (IBW, FBW, FER, BWG%) for rats. Blood samples were separated into serum for liver functions determination (ALT, AST and ALP) , lipid profile parameters (TC, TG, HDL-C, LDL-C and VLDL-C) and antioxidant parameters determination (MDA and GPx). The increase in IBW, FBW, BWG% and FER were significantly ameliorated by the administration of Senna leaves treatments, compared to hepatotoxicity rats. The results revealed that in CCl4 group, there were significant increases in ALT, AST, ALP ,TC, TG, LDL-C , VLDL-C and MDA, while parameters HDL-C and GPx showed significant decreases. Meanwhile, administration of Senna leaves resulted in a significant decrease in all elevated mentioned parameters and increase in HDL and GPx. Therefore, it could be concluded that Senna leaves have hepatoprotective and antioxidant role.
A. Amin, Ahmed, M. Hassan, Nehal, & O. Aboraya, Alaa. (2023). Antioxidant and Hepatoprotective effect of Senna leaves (Cassia senna l.) against carbon tetrachloride induced hepatotoxicity in rats. مجلة الاقتصاد المنزلي, 39(2), 29-44. doi: 10.21608/jhe.2023.442197
MLA
Ahmed A. Amin; Nehal M. Hassan; Alaa O. Aboraya. "Antioxidant and Hepatoprotective effect of Senna leaves (Cassia senna l.) against carbon tetrachloride induced hepatotoxicity in rats", مجلة الاقتصاد المنزلي, 39, 2, 2023, 29-44. doi: 10.21608/jhe.2023.442197
HARVARD
A. Amin, Ahmed, M. Hassan, Nehal, O. Aboraya, Alaa. (2023). 'Antioxidant and Hepatoprotective effect of Senna leaves (Cassia senna l.) against carbon tetrachloride induced hepatotoxicity in rats', مجلة الاقتصاد المنزلي, 39(2), pp. 29-44. doi: 10.21608/jhe.2023.442197
VANCOUVER
A. Amin, Ahmed, M. Hassan, Nehal, O. Aboraya, Alaa. Antioxidant and Hepatoprotective effect of Senna leaves (Cassia senna l.) against carbon tetrachloride induced hepatotoxicity in rats. مجلة الاقتصاد المنزلي, 2023; 39(2): 29-44. doi: 10.21608/jhe.2023.442197
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