The Bioactive Effect of Round Purple Turnip Roots against Carbon Tetrachloride-Induced Hepatotoxicity in Rats

Many of the ordinarily used medications may cause liver injury as an adverse reaction that is unpredictable and produce a significant possibly serious acute and chronic liver injury. This study was carried out to investigate the bioactive effects of round purple turnip roots (RPTRs) against CCl₄-induced hepatotoxicity in rats. Thirty-five albino rats of Sprague-Dawley strain were randomly distributed into five groups, group 1 (negative control, 7 rats) was feeding on the basal diet. The rest groups (2, 3, 4 and 5) were intraperitoneal injected once a week for six weeks with CCl₄ to induce acute the liver toxicity. Group 2 was used as positive group and feed on the basal diet, while groups 3, 4 and 5 feed in the complementary diet with 5, 7.5 and 10% of RPTRs, respectively. The outcome commented that untreated hepatotoxicity-rats possess a significant (P<0.05) diminishing in FI, BWG, and BWG %, and serum TP and Alb levels, and activity of CAT, SOD, and GSH. While, the serum levels of UN, Cr, UA, TL, TG and TC, and activity of antioxidant and liver enzymes were increased, compared to the negative control group. Additionally, several degradation were marked in the hepatic lobules, congestion in both the blood sinusoids and central veins, ragmented nuclei hepatic cells and the presence of inflammatory cell infiltration and a dilated congested portal vein in positive group. In comparison to the positive group, the complemented diet with the three different levels of RPTRs caused a significant ameliorated in all of the biological and biochemical tested parameters, as well histological structure of liver, on dose dependent manner. Finally, this study concluded that RPTRs have a significant beneficial health effects that caused ameliorated on the functions of liver injury that may attribute to its bioactive compounds.