نوع المستند : المقالة الأصلية
المؤلفون
1
Nutrition and Food Science Dept., Faculty of Home Economics, Helwan University
2
Graduate student, Nutrition and food science Dept, Faculty of Home Economics , Helwan University, Egypt
3
Nutrition and Food Science, Nutrition and Food Science Dept., Faculty of Home Economics, Arish University
المستخلص
Obesity is linked to chronic inflammation and oxidative stress, leading to metabolic disorders and liver damage. This study examined the anti-inflammatory and antioxidant effects of olive leaves, Plantago ovata, and ginger, individually and in combination, in an obesity-induced rat model. Sixty male Wistar rats were assigned to six groups: control (standard diet), hyperlipidemic (high-fat diet), and four treatment groups receiving a high-fat diet supplemented with 5% Plantago ovata, olive leaves, ginger, or their combination for eight weeks. Body weight and feed efficiency ratio were recorded. Blood and liver samples were analyzed for antioxidant enzymes (SOD, GSH-Px, CAT), while the inflammatory markers (IL-6, leptin) were determined using ELISA. Histopathological liver examinations assessed structural changes. The treatment groups showed significant reductions in final body weight compared to the hyperlipidemic group, with the combination treatment having the most pronounced effect. Feed efficiency ratio improved across all treatment groups, especially in the combination group. IL-6 and leptin levels were significantly lower, with ginger and the combination treatment exhibiting the strongest anti-inflammatory effects. Antioxidant enzyme activities (catalase, GPx, and SOD) were enhanced in all treatment groups, with the combination treatment showing the greatest improvement, indicating strong antioxidant potential. Histopathological analysis confirmed hyperlipidemia-induced liver damage, while plant-based treatments provided varying degrees of hepatoprotection. Olive leaves, Plantago ovata, and ginger reduced steatosis and inflammation, with the combination treatment offering the highest protective effects. These findings suggest that combining these plant-based treatments exerts a synergistic effect, improving metabolic and inflammatory disturbances in obesity. Further research is needed to explore their potential as natural therapeutic agents for obesity-related complications
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