نوع المستند : المقالة الأصلية
المؤلفون
1
Nutrition and Food Science Dept., Faculty of Home Economics, Helwan University
2
Graduate student, Nutrition and food science Dept, Faculty of Home Economics, Helwan University, Egypt
3
Nutrition and Food Science, Nutrition and Food Science Dept., Faculty of Home Economics, Arish University
المستخلص
Obesity increases cardiovascular risk, causes insulin resistance, and increases oxidative stress, leading to NAFLD and CKD. This study aims to evaluate the therapeutic potential of olive leaf, Plantago ovata seeds, and ginger in combating obesity in rats. Sixty male Wistar rats were divided into six groups: a control group (standard diet), a hyperlipidemic group (high-fat diet), and four treatment groups receiving a high-fat diet supplemented with 5% Plantago ovata, olive leaves, ginger, or their combination for eight weeks. Body weight and feed efficiency ratio were monitored. Blood and brain samples were analyzed to evaluate lipid profile, glucose levels, liver enzyme activity, kidney function, (oxidative stress markers and antioxidant enzymes) in the brain, were measured. The treatment groups exhibited significant weight reduction compared to the hyperlipidemic group, with the combination treatment showing the greatest effect. Additionally, the feed efficiency ratio improved in all treatment groups, particularly in the combination group. The study assessed the effects of olive leaves, psyllium, ginger, and their combination on lipid profile and glucose levels in hyperlipidemic rats. The combination group showed the greatest improvements, significantly reducing cholesterol, LDL-c, and glucose while increasing HDL-c. The tested materials and their combination improved liver and kidney function in hyperlipidemic rats, with the combination group showing the most significant reduction in AST, ALT, and creatinine levels. Olive leaves, psyllium, ginger, and their combination enhanced antioxidant enzyme activity and reduced oxidative stress in the brains of hyperlipidemic rats. The combination group exhibited the greatest decrease in MDA levels and the highest catalase, Gpx, and SOD activity. This study concluded the following: Treatment groups, especially the combination group, showed significant weight reduction, improved lipid profile, glucose levels, and liver and kidney functions. Antioxidant enzyme activity increased, while oxidative stress marker decreased, highlighting the potential of these supplements in obesity management.
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