A Comparative Study of the Effect of some Nuts on Gout in Rats

نوع المستند : المقالة الأصلية

المؤلفون

1 Faculty of Home Economics, Helwan University

2 Faculty of Nutrition Sciences Helwan University

المستخلص

This study was conducted to investigate the potential effect of some nuts (peanuts, almonds, and walnuts) on rats with gout. Thirty adult male Sprague-Dawley rats (180 ± 5 g) were tested. Gout was induced in rats by injected intradermally with a one single dose of 0.2 ml (4mg) into the right footpad uric acid crystals into the right sole of the foot. The thirty rats were divided into five groups as follows: Group (1) was fed a basal diet (as a negative control group). Group (2) was fed a basal diet and was intradermally injected with a single dose of monosodium uric acid crystals  0.2 ml   (4 mg)), serving as a positive control group. Group (3) of rats with gout was fed a basal diet supplemented with 10% dried peanuts. Group (4) of rats with gout was fed a basal diet supplemented with 10% dried walnuts. Group (5) of gout-affected rats were fed a basal diet supplemented with 10% dried almonds. Biological evaluation of the diet was performed by determining the feed intake, body weight gain, and feed efficiency. At the end of the experimental period (6 weeks), the rats were slaughtered to obtain blood serum. The serum was used to determine kidney function: urea, uric acid, and creatinine; oxidative biomarkers: malondialdehyde and superoxide dismutase; and liver function (aspartate aminotransferase activity and alanine aminotransferase activity). The results showed a significant decrease in liver function, oxidative biomarkers, urea, creatinine, and uric acid in the groups fed nuts compared to the positive control group, while blood proteins (albumin, globulin, total protein, and final body weight) of the group fed nuts significantly increased compared to the positive control group

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