The Potential Effects of Egg White, Soybean Milk and Crestor (Rosuvastatin calcium) Medication on Nonalcoholic Steatohepatitis in Rats

نوع المستند : المقالة الأصلية

المؤلفون

1 Nutrition, Nutrition and Food Sciences Dept., Faculty of Home Economics Helwan University

2 Histology and Cell Biology - Cairo University

المستخلص

Fatty liver disease is a condition in which fat builds up in the liver. There are two foremost types of it: non-alcoholic fatty liver disease (NAFLD) and alcoholic fatty liver disease. NAFLD also known as nonalcoholic steatohepatitis (NASH). It is a metabolic disease-related fatty liver disease with insulin resistance. This study was carried out for finding the effects of Crestor (Rosuvastatin calcium) as a medical therapy, and egg white and soybean milk as a dietary treatment of NASH rats. Nonalcoholic steatohepatitis (NASH) was induced by feeding rats for 6 weeks on a high-fat diet. After that, NASH-rats were fed HFD with daily given orally crestor medication (10 mg/kg), egg white, soy milk and the mixture of them (2 ml/100g). The results discovered that the oral administration of soy milk, egg white and the mixture of the three treatments significantly reduces body weight, visceral fat weight, adiposity index of fat, compared to that of the treated NASH rats with crestor and positive group. On the other hand, the improvement in the serum levels of TL, TC, TG, LDL-c, and VLDL-c was more evident in NASH rats treated by the administration of Crestor or the mixture of the three treatments, compared to that treated with soy milk and egg white. While serum levels of HDL-c, TP, Alb, TBL, DBL, IDBL and MDA, and the activities of liver enzymes and antioxidant enzymes in NASH rats treated with soy milk and egg white were more improved, compared to that treated with the Crestor or the mixture of the three treatments. The results of the above biochemical parameters were confirmed by the results of the histopathological examination of the liver. In conclusion, egg white and soy milk induced reduction in body weight and visceral fat, as well as hepatoprotective and antioxidant activities in NASH rats fed on the HFD. However, the study needs more investigation to detect the action mechanism of them.

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