The Protective Effect of Ginkgo Biloba Leaves on Oxidative Stress in Rats with Induced Liver Toxicity

نوع المستند : المقالة الأصلية

المؤلفون

1 Nutrition and Food Science Department, Faculty of Home Economics, Helwan University

2 Faculty of Nutrition Science, Helwan University

3 Regional Center of Food and feed, Agriculture Research Center

المستخلص

Ginkgo (Ginkgo biloba L.) is one of the most distinctive plants, characterized by excellent resistance to various environmental conditions. It is used as a medicinal plant in both traditional and Western medicine. The aim of the present study was to investigate the effect of dried Ginkgo biloba leaves on oxidative stress as well as on liver functions of rats with induced liver toxicity. Thirty adult male albino rats (Sprague-Dawley strain), weighing about 180 ± 10 g,were divided randomly into two main groups as follows: the first group (negative control= 5 rats) was fed on basal diet. The second group (25 rats) was fed a basal diet then these rats were classified as the positive control group fed on basal diet only, however the other rats were fed on basal diet supplemented with dried ginkgo biloba at levels of  2.5%, 5% ,7.5% and 10% , respectively. After four weeks from the start of the experiment, the second groups from 2 to 5 were injected intraperitoneally with CCl₄  1mL/kg BW, a (1:1) mixture with corn oil for 3 days to induce liver toxicity. The existing study illustrated that Ginkgo biloba leaves at the four tested levels could significantly improve (P<0.05) the liver functions and lipid profile, increasing the activity of antioxidant enzymes and lowering the oxidative stress by eliminating the deleterious toxic effect of CCl₄, especially with the higher levels of Ginkgo biloba. The findings indicated that ginkgo leaves may have a protective effect role on the oxidative stress in rats with induced liver toxicity.

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