Anti-ulcer effect of Jasminum grandiflorum L. Extract on Gastric Ulceration in Rats

نوع المستند : المقالة الأصلية

المؤلفون

1 Regional Center for Food and Feed, Agricultural Research Center, Giza, Egypt

2 Nutrition and Food Science Dept., Home Economics Faculty, Helwan University

المستخلص

Globally, gastric ulcer is one of the most serious diseases. Although, there are several antiulcer drugs, however most of them have adverse reactions. This research aims to investigate the protective effects of Jasminum Grand Flower Extract (JGFE) in three levels against indomethacin (IND)-induced gastric ulcer in rats. Gastric ulcer was induced by a single oral dose of IND (30 mg/ kg). JGFE were administered orally at a dose of 200,400 and 600 mg/ kg b.wt.           for 14 days prior to IND ingestion. Gross evaluation of gastric mucosal lesions showed that JGFE at the three tested levels significantly (P<0.05) diminished ulceration of surface epithelium, and maintained the normal histological structure of gastric mucosa induced by IND. Besides, significant (P<0.0.5) reduction in length of Gastric Ulcer, volume of gastric juice as well as decreased serum malondialdehyde as compared with the +ve group. Pretreatment with JGFE at the three tested levels significantly (P<0.05) increased the gastric PH and serum Superoxidase dismutase, catalase and glutathione. Moreover, JGFE at 400 and 600 showed a better ulcer healing capacity as compared with the dose of 200 mg/kg b.wt. Conclusion, pretreatment with JGFE alleviated gastric mucosal ulceration due to its high activity of active antioxidant.

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